Signature Library: Normals

The range of normal Sonoclot Signatures is extensive because the Sonoclot Signature detects mechanical changes occurring throughout the multiple steps of hemostasis. The following Sonoclot Signatures are provided to illustrate the range of normals for the different stages of clot development including the coagulation cascade, fibrin gel formation and clot retraction.

Clot retraction is the phase of the Sonoclot Signature that has the broadest spectrum of shapes. The examples vary from single well-defined peaks capturing rapid clot retraction through poorly defined peaks that show little evidence of clot retraction. Strong clot retraction indicates good platelet function. Weak or poorly defined clot retraction indicates either low platelet count or poor platelet function.

    

The Sonoclot Signature to the left has an Onset time of 111 seconds and a Clot RATE of 22. Both of these results are within normal ranges. The clot retraction has a well defined peak at approximately 10 minutes and reaches completion within 25 minutes. This is good clot retraction.


    Clot retraction is rarely faster than this example with a Time to Peak of 6 minutes and full retraction in 11 minutes.

    The clot retraction in this example, Time to Peak: 14 minutes and full retraction in 29 minutes is well defined and shows good platelet function.

    Many normal Sonoclot Signatures will begin with a small peak before the primary peak. In this example the Time to Peak is actually 11.5 minutes not 5 minutes. One useful rule of thumb for results using the SonACTTM P/N 800-0432 test is: The Time to Peak is often approximately half the time for complete retraction. Based on this rule of thumb and observing that complete retraction occurs in 27 minutes, the primary peak would be expected to occur at 13.5 minutes which is in close agreement with the actual Time to Peak, 11.5 minutes.


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This page was last modified on 10/26/07
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